ABSTRACT
The outbreak of the new coronavirus (SARS-CoV-2) causing the coronavirus disease (COVID-19) has spread globally. As of June 18, 2020, a high maternal mortality rate due to SARS-CoV-2 infections was identified in Brazil, representing most of the world cases at that time. An observational, cross-sectional study was performed with pregnant women admitted in two maternity hospitals located in Salvador/Bahia and their newborns, from May 24th up to July 17th of 2020. Among 329 pregnant women enrolled at hospital admission, a high prevalence (n=28; 8.5%) of pregnant women with COVID-19 was observed, as well as a high proportion of asymptomatic cases (n=19; 67.9%). Two newborns had detectable SARS-CoV-2 but evolved without abnormalities. This data highlight the importance of identifying pregnant women with COVID-19 for proper isolation measures to prevent in-hospital transmission.
Subject(s)
COVID-19 , Pregnancy Complications, Infectious , Brazil/epidemiology , Cross-Sectional Studies , Female , Hospitals, Maternity , Humans , Infant, Newborn , Infectious Disease Transmission, Vertical , Pregnancy , Pregnancy Complications, Infectious/epidemiology , Pregnancy Outcome , Pregnant Women , SARS-CoV-2ABSTRACT
ABSTRACT The aim of this research was to understand the impacts that working from home during the COVID-19 quarantine period had on the work-family conflict for Brazilian female workers. To reach the objective, fourteen professionals with different family arrangements, were interviewed. All the interviewees reported work overload due to organizational requirements, and the demands placed on them by their children and the home. Despite this, it is worth noting that, according to the testimonies, this work overload did not intensify the work-family conflict for all of them, contrary to what is claimed in the literature. Some interviewees stated that working from home brought them closer to their children and husbands and provided more time for physical and leisure activities. This finding can contribute towards broadening the debate on work-family conflict, by postulating that it is not only time, pressure and behavior that are the sources of this conflict, but also the physical distance imposed by the hours spent working away from the home.
ABSTRACT
Esta pesquisa objetivou compreender os impactos que a adoçâo do home office, no período da quarentena da Covid-19, teve no conflito trabalho-família vivida por trabalhadoras brasileiras. Para alcançar o objetivo, foram entrevistadas 14 profissionais com diferentes arranjos familiares. Todas as entrevistadas relataram sobrecarga de trabalho devido as exigencias organizacionais, as demandas com os filhos e com a casa. Apesar disso, cabe destacar que, de acordo com os depoimentos, a sobrecarga de trabalho nāo intensificou o conflito trabalho-família para todas, o que vai na contramāo do previsto na literatura. Algumas entrevistadas alegaram que o home office aproximou-as dos filhos e maridos e propiciou mais tempo para atividade físicas e de lazer. Tal achado pode contribuir para ampliar o debate sobre o conflito trabalho-família, muitas vezes conflituosa, ao postular que nāo apenas o tempo, a pressāo e o comportamento sāo fontes deste conflito, mas também a distancia física que as horas dedicadas ao trabalho fora de casa requerem.Alternate abstract:The aim of this research was to understand the impacts that working from home during the COVID-19 quarantine period had on the work-family conflict for Brazilian female workers. To reach the objective, fourteen professionals with different family arrangements, were interviewed. All the interviewees reported work overload due to organizational requirements, and the demands placed on them by their children and the home. Despite this, it is worth noting that, according to the testimonies, this work overload did not intensify the work-family conflict for all or them, contrary to what is claimed in the literature. Some interviewees stated that working from home brought them closer to their children and husbands, and provided more time for physical and leisure activities. This finding can contribute towards broadening the debate on work-family conflict, by postulating that it is not only time, pressure and behavior that are the sources of this conflict, but also the physical distance that the hours spent working away from the home imposes.Alternate abstract:Esta investigación tuvo como objetivo comprender los impactos que la adopción del home office, durante el período de cuarentena de la COVID-19, tuvo sobre la relación trabajo-familia de las trabajadoras brasileñas. Para alcanzar el objetivo se entrevistaron catorce profesionales, con diferentes arreglos familiares. Todas las entrevistadas relataron sobrecarga laboral debido a las exigencias organizativas, obligaciones con sus hijos y con el hogar. A pesar de ello, cabe señalar que, según los testimonios, para ninguna de ellas la sobrecarga laboral dificultó la administración de la relación trabajo-familia, al contrario de lo previsto en la literatura. Algunas entrevistadas afirmaron que trabajar en el hogar las acercó a sus hijos y maridos y les proporcionó más tiempo para actividades físicas y de recreación. Este hallazgo puede contribuir a ampliar el debate sobre la relación trabajo-familia, a menudo conflictiva, al postular que no solo el tiempo, la presión y el comportamiento son fuentes de ese conflicto, sino también la distancia física impuesta por las horas dedicadas al trabajo fuera del hogar.
ABSTRACT
Background: Coronavirus disease 2019 (COVID-19) associated- severe acute respiratory distress syndrome (ARDS) patients may require prolonged mechanical ventilation, thus resulting in lung fibrosis and high fatality rates. Several therapies have been developed in patients with pneumonia requiring oxygen therapy as well as during the early course of invasive mechanical ventilation. Mesenchymal stromal cells (MSCs) may have a role in controlling the hyperinflammatory response seen in such cases and prevent aggravation or increase/accelerate recovery. While MSC-based therapies have been studied mostly in patients that did not require invasive ventilation or during the first hours of tracheal intubation, to date the potential of MSC therapy to treat advanced-stage of severe/critical COVID-19 cases has not been extensively studied. Methods: This is a case report of a 30-year-old male patient who presented progressive clinical deterioration of COVID-19 in ICU after 21-day admission and 14 days with invasive mechanical ventilation. The first symptom onset was 35 days before MSC therapy. The patient was treated with allogenic human umbilical cord-derived MSCs [5 x 107 (2 doses 2 days interval)].Results: No serious adverse events attributed to MSC administration were observed during and after the procedure. Oxygenation (PaO2/FiO2 ratio) and the need for vasoactive drugs improved. Chest CT scan imaging, which showed signs of bilateral and peripheral ground-glass, consolidation as well as fibrosis, improved significantly during the time course of the disease. Patient was discharged 13 days after cell therapy. Cytokine analysis demonstrated modulation of different mediators accompanied by modulation of different cell populations in peripheral blood, including a reduction in inflammatory monocytes, increased frequency of patrolling monocytes, CD4+ lymphocytes and type 2 classical dendritic cells (cDC2). Conclusion: This study described for the first time the effects of MSC therapy in a patient at late stage COVID-19 associated severe lung injury and fibrosis. Therefore, further clinical trials should be design assessing the efficacy of MSC therapy in ARDS patients undergoing prolonged mechanical ventilation due to COVID-19.